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TU Dortmund
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News:
12/18/2023
New Study by the Team of Dr. Dehmelt Uncovers Fundamental Mechanism in Cell Migration
Rho GTPase family member Rac1 is only active in cell protrusions and the related family member RhoA only in cell contractions. Contrary to previous assumptions, however, Rac1 and RhoA do not inhibit each [...] decipher the mechanism by which Rac1 activates RhoA. The group found that this occurs via the signaling molecules Arhgef11 and Arhgef12, which are themselves activated by Rac1 and can then activate RhoA. By [...] each other; instead, Rac1 positively influences RhoA and activates it. The team hypothesized that this unexpected coupling plays a role in generating dynamic cycles of alternating cell protrusion and cell …