-
GRK 2624
-
Research
-
Projects
I1: RiskScore
I1: RiskScore Weighted risk scores for the assessment of cumulative risks Project I1 associates omics data with the clinical phenotype of aged human skin. Aging processes are determined by genetic factors [...] predictors in an integrated regression model for the skin aging phenotype (Y), given by Y = β 0 + β 1 RS RNAseq + β 2 RS proteome + β 3 RS secretome . The risk scores are weighted using regularised regression [...] scores with internal weights from elastic net regression. BMC Genet 18, 55, doi: 10.1186/s12863-017-0519-1 . Hüls A, Krämer U, Carlsten C, Schikowski T, Ickstadt K, Schwender H (2017b). Comparison of weighting …